The pair, both Ghana internationals, have faced off in the past in the Premier League when representing both Swansea and Aston Villa respectively, but also have a long running history of playing together.
Not only have the duo represented their country nearly 50 times together, they also spent a number of seasons together in Ligue 1 with former club Marseille.
However brotherly love will once again go out in the window this weekend, and Andre hopes it is he who can walk away with the sibling bragging rights.
“As usual, any time I play against my little brother, the whole family is up to it,” Andre told whufc.com. “Everyone comes over, the whole family, whether it’s in London or in Swansea, so now we’re playing at home first, so it’s going to be good. Most importantly, we need the points.
“Our paths cross a lot, because most of the time we’ve played in the same league, so we’ve been lucky enough to play versus one another, and also together for Marseille and in the national team too.”
The famous sons of African footballing legend Abedi ‘Pele’ Ayew, West Ham’s Andre believe they have have unique opportunity in the world of football when they meet on Saturday.
“Not a lot of brothers have the chance to feel what we are experiencing, so I feel we are blessed and our family is blessed. Football has given us so much, so we just need to give back to the game.”