The Hammers have not won since September in the top-flight, and sit just above the relegation zone after losing to Burnley 3-0 at Turf Moor last time out.
Mark Noble was forced off in that clash after picking up an injury, something which could leave Manuel Pellegrini with limited options moving forward.
Declan Rice is almost certain to play in holding midfield in his captain’s absence, and Carlos Sanchez has already proved that he isn’t good enough to consistently cement his spot in the side.
The Colombian has only started games in the Carabao Cup this season and has come off the bench in three Premier League games, he has yet to make a single tackle, clearance or interception according to WhoScored.
The online outlet claim on their website that the Serbian international doesn’t necessarily want to leave Old Trafford, but would consider an exit given his situation.
Matic’s experience would be a great option to have in holding midfield, and he would almost be guaranteed a starting spot given the nightmare that Pellegrini is having with his side.
It might not be as straight-forward as that though, with the Times reporting that the midfielder is more likely to end up in Italy should he move away from the Red Devils.
With his likely destination now being elsewhere, it looks like West Ham are facing an uphill battle to secure his services midway through the season.